The viscous behaviour of HES 130/0.4 (Voluven®) and HES 260/0.45 (Pentaspan®)

Pediatric hypereosinophilic syndrome (HES) differs from adult HES.

The idiopathic hypereosinophilic syndrome (HES) developed in a 15-year-old boy who presented with colitis, cough, rash, and hepatitis. Molecular analysis failed to demonstrate the Fip1-like1-Platelet Derived Growth Factor Receptor alpha chain (FIP1L1-PDGFRA) mutation described in adult patients with HES. There are significant clinical differences between the pediatric and adult presentations of...

Recombination in hES cells

The study of protein structure and function is often greatly facilitated by the introduction of various biophysical probes directly onto the protein of interest. Though recombinant and cell-free expression systems for incorporating probes are rapidly developing, chemical methods of probe introduction are now robust and valuable technologies. Muralidharan and Muir present a practical guide for u...

Comparison of HES 130/0.42 and HES 200/0.5 for hemodynamic stabilisation in major urological surgery

Purpose: Different hydroxyethyl starches (HES) may lead to different volume effects. We compared a new HES130/0.42 with an established HES200/0.5 with respect to perioperative volume requirements, hemodynamic effects, safety and tolerability. Methods: After approval of the local ethics committee we investigated in a prospective, randomized double-blinded clinical trial 100 adult patients schedu...

HES 130/0.42 shows less alteration of pharmacokinetics than HES 200/0.5 when dosed repeatedly.

BACKGROUND Hydroxyethyl starches (HES) accumulate in the circulation when administered repeatedly. Accumulation is thought to be partly responsible for undesirable effects (tissue storage, blood coagulation impairment, and itching). HES 130/0.42 with low molecular weight and a low level of substitution has recently been developed in order to reduce those risks. METHODS In healthy volunteers, ...

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